Check out odds, insights and more in our betting preview for the USC Trojans vs. Colorado Buffaloes college football matchup on October 2, 2021.

The USC Trojans (2-2, 0-0 Pac-12) are 7.5-point favorites when they visit the Colorado Buffaloes (1-3, 0-0 Pac-12) in a Pac-12 matchup on Saturday, October 2, 2021 at Folsom Field. The total has been set at 51 points for this game.
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Odds for USC vs. Colorado
Odds courtesy of SI Sportsbook.
Over/Under Insights
- USC has combined with its opponents to score more than 51 points in three of four games this season.
- Colorado and its opponents have not yet combined to score more than 51 points in a game this season.
- Saturday’s over/under is 4.7 points higher than the combined 46.3 PPG average of the two teams.
- This contest’s total is 3.5 points above the 47.5 these two squads combine to allow per game this season.
- The average total in Trojans games this season is 59.5, 8.5 points above Saturday’s total of 51.
- In 2021, games involving the Buffaloes have averaged a total of 48.2 points, 2.8 fewer than this game’s set over/under.
USC Stats and Trends
- USC has two wins against the spread in four games this year.
- The Trojans have covered the spread twice this season when favored by 7.5 points or more (in four chances).
- USC’s games this year have hit the over on two of four set point totals (50%).
- This year, the Trojans average 12.0 more points per game (32.5) than the Buffaloes surrender (20.5).
- When USC puts up more than 20.5 points, it is 2-2 against the spread and 2-2 overall.
- The Trojans average 69.5 more yards per game (425.5) than the Buffaloes give up per matchup (356.0).
- USC is 2-2 against the spread and 2-2 overall when the team totals over 356.0 yards.
- The Trojans have turned the ball over nine times this season, seven more turnovers than the Buffaloes have forced (2).
- Find the latest spread and moneyline odds for USC at SISportsbook.
Colorado Stats and Trends
- Colorado has one win against the spread in four games this season.
- The Buffaloes have been underdogs by 7.5 points or more two times this season and covered the spread once.
- Colorado’s games this season have gone over the total in one out of three opportunities (33.3%).
- The Buffaloes average 13.8 points per game, 13.2 fewer than the Trojans allow (27.0).
- The Buffaloes collect 239.0 yards per game, 152.3 fewer yards than the 391.3 the Trojans allow.
- This year the Buffaloes have three turnovers, five fewer than the Trojans have takeaways (8).
- Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.















