Check out odds, insights and more in our betting preview for the Clemson Tigers vs. Syracuse Orange college football matchup on October 15, 2021.

The Clemson Tigers (3-2, 0-0 ACC) will put their 22nd-ranked run defense to the test against the Syracuse Orange (3-3, 0-0 ACC) and the No. 11 running attack in college football, on Friday, October 15, 2021. The Tigers are heavily favored by 14 points in the game. The total has been set at 45 points for this game.
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Odds for Clemson vs. Syracuse
Odds courtesy of SI Sportsbook.
Over/Under Insights
- Clemson has combined with its opponents to score more than 45 points only twice this year.
- So far this season, 66.7% of Syracuse’s games (4/6) have had more combined points than Friday’s total of 45.
- Friday’s over/under is 7.7 points lower than the two team’s combined 52.7 points per game average.
- The 36.2 combined points per game that these two squads have allowed this season are 8.8 fewer than the 45 total in this contest.
- The average total in Tigers games this season is 50.7, 5.7 points above Friday’s total of 45.
- The 45-point over/under for this game is 6.9 points below the 51.9 points per game average total in Orange games this season.
Clemson Stats and Trends
- Clemson has not covered the spread yet this season.
- This season, the Tigers are winless ATS when entering a game as a favorite of 14 points or more (in three chances).
- Clemson’s games this year have gone over the total in one out of five opportunities (20%).
- This year, the Tigers average just 2.8 fewer points per game (21.2) than the Orange surrender (24.0).
- The Tigers rack up only 15.8 more yards per game (324.0) than the Orange give up per outing (308.2).
- In games that Clemson churns out over 308.2 yards, the team is 0-2 against the spread and 2-0 overall.
- The Tigers have six turnovers this season, equal to the number of takeaways for the Orange.
- Find the latest spread and moneyline odds for Clemson at SISportsbook.
Syracuse Stats and Trends
- Syracuse has five wins against the spread in six games this season.
- Syracuse’s games this year have eclipsed the over/under in 50% of its opportunities (three times in six games with a set point total).
- This season the Orange score 19.3 more points per game (31.5) than the Tigers allow (12.2).
- When Syracuse records more than 12.2 points, it is 5-0 against the spread and 3-2 overall.
- The Orange rack up 103.4 more yards per game (412.0) than the Tigers allow per matchup (308.6).
- In games that Syracuse picks up over 308.6 yards, the team is 4-0 against the spread and 2-2 overall.
- The Orange have seven turnovers this season, equal to the number of takeaways for the Tigers.
- Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.















