Check out odds, plays and more for the San Francisco 49ers vs. Indianapolis Colts NFL Week 7 matchup on October 24, 2021.

The San Francisco 49ers (2-3) are favored by 4 points as they attempt to end their three-game losing streak in a matchup with the Indianapolis Colts (2-4) on Sunday, October 24, 2021 at Levi’s Stadium. The point total is set at 44 for the contest.
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Odds for 49ers vs. Colts
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Over/under insights
- San Francisco and its opponents have gone over the current 44-point total in three of five games this season.
- Indianapolis has combined with its opponents to score more than 44 points in four of six games this season.
- The combined points per game average of the two teams, 46.6, is 2.6 points greater than Sunday’s over/under.
- These two squads surrender a combined 45.6 points per game, 1.6 more than this contest’s over/under.
- 49ers games this season feature an average total of 49.2 points, a number 5.2 points higher than Sunday’s over/under.
- The 46.1 PPG average total in Colts games this season is 2.1 points more than this game’s over/under.
49ers stats and trends
- San Francisco has one win against the spread in five games this season.
- The 49ers have yet to cover the spread this season when favored by 4 points or more.
- San Francisco’s games this year have gone over the total in two out of five opportunities (40%).
- The 49ers put up just 1.6 more points per game (23.4) than the Colts surrender (21.8).
- San Francisco is 0-2 against the spread and 1-1 overall this season when the team puts up more than 21.8 points.
- The 49ers average only 1.7 more yards per game (368.2) than the Colts allow per contest (366.5).
- In games that San Francisco piles up more than 366.5 yards, the team is 0-2 against the spread and 1-1 overall.
- The 49ers have turned the ball over seven times this season, five fewer than the Colts have forced (12).
- Click over to SISportsbook and find the latest spread, moneyline and total for San Francisco’s matchup with the Colts.
Colts stats and trends
- In Indianapolis’ six games this season, it has four wins against the spread.
- The Colts have covered the spread twice this year when underdogs by 4 points or more (in three chances).
- Indianapolis has hit the over in 50% of its opportunities this season (three times over six games with a set point total).
- The Colts rack up 23.2 points per game, comparable to the 23.8 the 49ers surrender.
- Indianapolis is 4-0 against the spread and 2-2 overall in games when it puts up more than 23.8 points.
- The Colts rack up 37.7 more yards per game (367.5) than the 49ers allow (329.8).
- Indianapolis is 4-1 against the spread and 2-3 overall when the team churns out more than 329.8 yards.
- This season the Colts have turned the ball over five times, three more than the 49ers’ takeaways (2).
Home and road insights
- 49ers home games this season average 51.3 total points, 7.3 more than this outing’s over/under (44).
- Indianapolis is 1-2 overall, with two wins against the spread, in away games.
- In three road games this season, Indianapolis has hit the over twice.
- Colts away games this season average 45.0 total points, 1.0 more than this matchup’s over/under (44).
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