Check out odds, insights and more in our betting preview for the Clemson Tigers vs. Syracuse Orange college football matchup on October 15, 2021.

The Clemson Tigers (3-2, 0-0 ACC) and the 22nd-ranked run defense will visit the Syracuse Orange (3-3, 0-0 ACC) and the 11th-ranked rushing attack on Friday, October 15, 2021. The Orange are 13.5-point underdogs. An over/under of 45.5 is set for the contest.
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Odds for Clemson vs. Syracuse
Odds courtesy of SI Sportsbook.
Over/Under Insights
- Clemson and its opponents have combined for 45.5 points — this matchup’s point total — only two times this year.
- So far this season, 50% of Syracuse’s games (3/6) have had more combined points than Friday’s total of 45.5.
- Friday’s over/under is 7.2 points lower than the two team’s combined 52.7 points per game average.
- The 36.2 combined points per game that these two squads have allowed this season are 9.3 fewer than the 45.5 total in this contest.
- The Tigers and their opponents have scored an average of 50.7 points per game in 2021, 5.2 more than Friday’s total.
- The 51.9 PPG average total in Orange games this season is 6.4 points more than this game’s over/under.
Clemson Stats and Trends
- Clemson has not covered the spread yet this year.
- This season, the Tigers are winless ATS when entering a game as a favorite of 13.5 points or more (in three chances).
- Clemson’s games this year have gone over the total in one out of five opportunities (20%).
- The Tigers score just 2.8 fewer points per game (21.2) than the Orange surrender (24.0).
- The Tigers average only 15.8 more yards per game (324.0), than the Orange give up per outing (308.2).
- In games that Clemson totals over 308.2 yards, the team is 0-2 against the spread and 2-0 overall.
- This year, the Tigers have turned the ball over six times, while the Orange have forced six.
- Find the latest spread and moneyline odds for Clemson at SISportsbook.
Syracuse Stats and Trends
- In Syracuse’s six games this season, it has five wins against the spread.
- Syracuse’s games this season have gone over the point total in 50% of its opportunities (three times in six games with a set point total).
- The Orange put up 31.5 points per game, 19.3 more than the Tigers give up (12.2).
- Syracuse is 5-0 against the spread and 3-2 overall in games when it scores more than 12.2 points.
- The Orange rack up 103.4 more yards per game (412.0) than the Tigers give up per matchup (308.6).
- In games that Syracuse amasses over 308.6 yards, the team is 4-0 against the spread and 2-2 overall.
- The Orange have seven turnovers this season, equal to the number of takeaways for the Tigers.
- Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.















