Check out odds, insights and more in our betting preview for the Michigan State Spartans vs. Indiana Hoosiers college football matchup on October 16, 2021.

The No. 10 Michigan State Spartans (6-0, 0-0 Big Ten) are favored by 4.5 points when they visit the Indiana Hoosiers (2-3, 0-0 Big Ten) in Big Ten action on Saturday, October 16, 2021 at Memorial Stadium. The contest’s point total is 48.5.
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Odds for Michigan State vs. Indiana
Odds courtesy of SI Sportsbook.
Over/Under Insights
- Michigan State and its opponents have combined to score more than 48.5 points in four of six games this season.
- Indiana’s games have gone over 48.5 points in three of five chances this season.
- The combined points per game average of the two teams, 60.5, is 12.0 points more than Saturday’s over/under.
- This contest’s over/under is 1.0 point greater than the 47.5 these two squads combine to allow per game this season.
- The Spartans and their opponents have scored an average of 54.2 points per game in 2021, 5.7 more than Saturday’s total.
- The 48.5-point total for this game is 4.7 points below the 53.2 points per game average total in Hoosiers games this season.
Michigan State Stats and Trends
- Michigan State is 4-1-1 against the spread this year.
- The Spartans have been favored by 4.5 points or more two times this season and covered the spread in one of them.
- Michigan State’s games this year have hit the over three times in six opportunities (50%).
- The Spartans average 8.5 more points per game (36.7) than the Hoosiers surrender (28.2).
- When Michigan State records more than 28.2 points, it is 4-0-1 against the spread and 5-0 overall.
- The Spartans average 135.7 more yards per game (487.3) than the Hoosiers allow per contest (351.6).
- In games that Michigan State piles up more than 351.6 yards, the team is 4-0-1 against the spread and 5-0 overall.
- This year, the Spartans have five turnovers, one fewer than the Hoosiers have takeaways (6).
- Find the latest spread and moneyline odds for Michigan State at SISportsbook.
Indiana Stats and Trends
- Indiana has covered the spread on one occasion this year.
- The Hoosiers have been underdogs by 4.5 points or more one time this year and have not covered the spread once.
- Indiana’s games this year have gone over the point total in 60% of its opportunities (three times in five games with a set point total).
- The Hoosiers score 4.5 more points per game (23.8) than the Spartans allow (19.3).
- When Indiana puts up more than 19.3 points, it is 1-2 against the spread and 2-1 overall.
- The Hoosiers collect 343.6 yards per game, 76.6 fewer yards than the 420.2 the Spartans give up.
- This season the Hoosiers have turned the ball over nine times, while the Spartans have forced 9 turnovers.
- Head to SISportsbook to find the latest moneyline, spread and over/under odds for this matchup.















