Check out odds, plays and more for the San Francisco 49ers vs. Arizona Cardinals NFL Week 9 matchup on November 7, 2021.

Packers Vs Cardinals
The Arizona Cardinals (7-1) are small, 2.5-point underdogs in a road NFC West matchup against the San Francisco 49ers (3-4) on Sunday, November 7, 2021 at Levi’s Stadium. The over/under is set at 45.
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Odds for 49ers vs. Cardinals
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Over/under insights
- San Francisco has combined with its opponents to put up more than 45 points in seven of nine games this season.
- In 75% of Arizona’s games this season (6/8), the teams combined to score more than Sunday’s total of 45.
- The combined points per game average of the two teams, 54.8, is 9.8 points above Sunday’s over/under.
- The 41.7 combined points per game that these two squads have allowed this season are 3.3 fewer than the 45 over/under in this contest.
- The 49ers and their opponents have scored an average of 47.1 points per game in 2020, 2.1 more than Sunday’s total.
- The 50.6 PPG average total in Cardinals games this season is 5.6 points more than this game’s over/under.
49ers stats and trends
- San Francisco has three wins against the spread in seven games this season.
- The 49ers are 3-5 ATS when favored by 2.5 points or more this season.
- San Francisco’s games this year have hit the over on four of nine set point totals (44.4%).
- This year, the 49ers rack up 6.7 more points per game (24.0) than the Cardinals give up (17.3).
- San Francisco is 2-5 against the spread and 2-3 overall this season when the team scores more than 17.3 points.
- The 49ers average 50.7 more yards per game (369.7) than the Cardinals give up per contest (319.0).
- San Francisco is 2-3 against the spread and 2-2 overall when the team churns out over 319.0 yards.
- The 49ers have turned the ball over 11 times this season, three fewer than the Cardinals have forced (14).
- Click over to SISportsbook and find the latest spread, moneyline and total for San Francisco’s matchup with the Cardinals.
Cardinals stats and trends
- Arizona has six wins against the spread in eight games this year.
- The Cardinals have an against the spread record of 3-0 in their three games as an underdog of 2.5 points or more this year.
- Arizona has hit the over in 37.5% of its opportunities this year (three times in eight games with a set point total).
- This season the Cardinals rack up 6.4 more points per game (30.8) than the 49ers allow (24.4).
- When Arizona puts up more than 24.4 points, it is 5-1 against the spread and 6-0 overall.
- The Cardinals average 69.6 more yards per game (393.6) than the 49ers allow per matchup (324.0).
- In games that Arizona amasses over 324.0 yards, the team is 5-2 against the spread and 6-1 overall.
- This year the Cardinals have turned the ball over nine times, four more than the 49ers’ takeaways (5).
Home and road insights
- San Francisco has not covered the spread at home, and is 0-4 overall there, this year.
- The 49ers are winless ATS (0-4) as 2.5-point favorites or greater at home.
- In four home games this season, San Francisco has gone over the total twice.
- 49ers home games this season average 48.8 total points, 3.8 more than this matchup’s over/under (45).
- On the road, Arizona is 4-0 overall and 4-0 against the spread.
- The Cardinals are unbeaten ATS (1-0) as 2.5-point underdogs or more on the road.
- In four away games this year, Arizona has gone over the total twice.
- The average point total in Cardinals away games this season is 51.9 points, 6.9 more than this matchup’s over/under (45).
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