Check out odds, plays and more for the New England Patriots vs. Buffalo Bills NFL Week 16 matchup on December 26, 2021.

AFC East foes will battle in Week 16 of the NFL season when the New England Patriots (9-5) meet the Buffalo Bills (8-6).
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Odds for Patriots vs. Bills
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Over/under insights
- New England’s games this season have gone over 43.5 points seven of 14 times.
- Buffalo’s games have gone over 43.5 points in seven of 14 chances this season.
- The two teams combine to average 54.3 points per game, 10.8 more than the total in this contest.
- This contest’s over/under is 9.9 points more than the 33.6 these two squads combine to surrender per game this season.
- The average total in Patriots games this season is 44.7, 1.2 points more than Sunday’s total of 43.5.
- The 48.2 PPG average total in Bills games this season is 4.7 points more than this game’s over/under.
Patriots stats and trends
- In New England’s 14 games this season, it has nine wins against the spread.
- The Patriots are 6-3 ATS when favored by 2.5 points or more this season.
- New England has eclipsed the over/under in 42.9% of its opportunities this year (six times over 14 games with a set point total).
- This year, the Patriots put up 8.8 more points per game (26.2) than the Bills surrender (17.4).
- New England is 7-2 against the spread and 8-1 overall in games when it records more than 17.4 points.
- The Patriots collect 60.0 more yards per game (347.9) than the Bills give up per contest (287.9).
- New England is 6-5 against the spread and 6-5 overall when the team picks up more than 287.9 yards.
- The Patriots have turned the ball over 18 times this season, nine fewer than the Bills have forced (27).
- Click over to SISportsbook and find the latest spread, moneyline and total for New England’s matchup with the Bills.
Bills stats and trends
- In Buffalo’s 14 games this season, it has eight wins against the spread.
- The Bills have covered the spread once this season when underdogs by 2.5 points or more (in two chances).
- Buffalo has gone over the point total in 50% of its opportunities this season (seven times in 14 games with a set point total).
- This year the Bills score 11.9 more points per game (28.1) than the Patriots give up (16.2).
- Buffalo is 8-2 against the spread and 8-2 overall in games when it scores more than 16.2 points.
- The Bills average 70.4 more yards per game (377.9) than the Patriots give up per contest (307.5).
- When Buffalo amasses more than 307.5 yards, the team is 8-4 against the spread and 8-4 overall.
- The Bills have 19 giveaways this season, while the Patriots have 27 takeaways.
Home and road insights
- New England is 3-4 overall, and 4-3 against the spread, at home.
- At home, the Patriots are 3-2 ATS as 2.5-point favorites or more.
- New England has gone over the total in four of seven games at home this year.
- Patriots home games this season average 45.4 total points, 1.9 more than this contest’s over/under (43.5).
- Buffalo is 4-3 overall, and 4-3 against the spread, on the road.
- The Bills are 3-2 ATS as 2.5-point underdogs or more away from home.
- Buffalo has gone over the total in four of seven away games this year.
- The average point total in Bills away games this season is 50.3 points, 6.8 more than this outing’s over/under (43.5).
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